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Obsidian/00.03 News/Could COVID-19 And Alzheime...

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Could COVID-19 And Alzheimer's Overlaps Point Towards A Solution For Both Diseases?

The medical community has suggested that calling Omicron “mild” is folly considering the reach of this most contagious COVID-19 variant, which continues to hospitalize the unvaccinated and move easily among the vaccinated. A leading concern is that surviving COVID infection is only half the battle for some people who can be left with debilitating symptoms, including brain damage that shares similarities with Alzheimers. While its hard to find a silver lining to the pandemic cloud, that we are learning new insights into “brain fog” brings some hope for the improved management of not just long COVID but Alzheimers, too.

A recent study published in the Journal of the Alzheimers Association found that patients with COVID-19 and associated neurological symptoms had raised levels of seven markers of brain damage, and that these were higher  in the short term  than those seen in patients with confirmed Alzheimers disease.

“Traumatic brain injury, which is also associated with increases in these biomarkers, does not mean that a patient will develop Alzheimers disease or related dementias later on, but does increase the risk of it,” said senior author Dr Thomas M. Wisniewski, director of the Center for Cognitive Neurology at NYU Langone, in a statement. “Whether that kind of relationship exists in those who survive severe COVID-19 is a question we urgently need to answer with ongoing monitoring of these patients.”

The connection is perhaps unsurprising in the context that cognitive symptoms reported with long COVID are similar to those of Alzheimers disease, including losing train of thought, difficulty grasping words, brain fog, memory loss, and personality changes.

High levels of beta-amyloid proteins could be one explanation for this, as these are known to build up in people who have Alzheimers disease. In the above mentioned study, these proteins were found to be raised among COVID-19 patients with neurological symptoms compared to other infected people without (for technical reasons, it wasnt possible to compare these concentrations to the participants with Alzheimers disease).

However, where this theory might fall down is in the result of several Alzheimers drug trials for medications that were thought to clear the brain of beta-amyloid proteins that found clearing them did little to improve patients symptom profiles.

An alternative theory looks to inflammation in the brain as a possible cause of neurodegeneration, something that can be triggered by viruses, bacteria, or fungi. This approach would tie in with the finding that many COVID-19 patients were struck by something called a cytokine storm, a condition in which the immune system battles infections but essentially goes overboard and begins attacking tissues that dont contain pathogens.

This kind of autoimmune response has the potential to attack brain cells causing short-term neurological symptoms and possibly increasing future risk of developing a neurological disorder. We need only look to another of Earths deadly pandemics for insight here, as the Spanish Flu saw over a million people who survived the infection go on to develop post-encephalitic Parkinsons disease, a harrowing condition depicted in the movie Awakenings (a great watch but one for which tissues are a necessity).

While the frustrating truth is that finding out if COVID-19 will lead to future cases of Alzheimers is a matter of watchful waiting (at least for now), the more we learn about the overlap of these two diseases, the greater opportunities we have for interrupting the processes that lead to neurodegeneration.